Impact of proliferative stress on both adaptive and innate immune response

Human ageing is by far one of the most complex biological phenomena which affects all cells and tissues, leading to gradual loss function, decrement in proliferative activity, impaired cellular response. One key mechanisms stress results telomeric attrition, DNA damage, deposition senescence-associated proteins. Allogeneic hematopoietic transplantation (allo-HCT) serves as a good model for ageing. Here we review immune system impact on both innate adaptive response, reflected immunosenescence inflammageing phenomena, context iatrogenic induced allo-HCT.